Treatments and Procedures
Bio-identical Hormone Replacement Therapy
- Eliminate night sweats and hot flashes
- Improve energy levels
- Improve mood
- Improve memory and concentration
- Improve sex drive
- Prevent vaginal thinning & dryness
- Improve fat loss and muscle tone
- Decrease skin winkles
- Protect bones from osteoporosis
- Reduce risks of heart disease
Bio-identical hormones have an identical molecular structure to the hormones naturally produced in the body and function in the same way as our own hormones.
Bio-identical progesterone and estrogen are processed from two natural sources (soy and wild yam) and are made into either a cream or as an oral supplement.
Acupuncture For Infertility
Pap And Physical Exam
The pap test is a screening test used to find abnormal cells in the cervix that might develop into cancer over time. Screening helps to find these abnormal cells early when they can be easily removed.
The physical exam ensures wellness and good health. It’s considered a preventive step and a way to catch a more serious condition before it begins to cause problems. Vitals like breast exam, blood pressure, heart rate, and other markers are monitored.
- it stimulates the immune system and
- it improves oxygenation and metabolism.
The modern development of ozone application in medicine began in the 1950s in Europe and gradually spread throughout Europe to Australia , Israel , Cuba , Brazil and Columbia. As far back as World War 1, ozone was used medically to treat wounds and other infections. Over 5000 physicians world-wide routinely use ozone in their medical practice.
Properties of Medical OzoneAt higher concentrations, ozone exhibits a strong germicidal effect by oxidative destruction. When used at the proper (lower) concentration, ozone is a safe “oxidizing” stimulus to cell membranes. Ozone behaves as an ion, not a free radical under normal physiologial blood pH and therefore no free radical chain reaction occurs causing oxidative damage. Ozone can increase oxygen transport, enhance cell membrane antioxidants and stimulate the immune system. At lower concentrations, ozone has two main properties:
- Ozone increases oxygen carrying ability of red blood cells, it stimulates the induction of specific enzymes on the surface of red blood cells.
- Ozone activates white blood cells by causing the production of cytokines.
Route Of AdministrationThere are several ways to administer ozone, depending upon the condition being treated. Colorectal insufflation of ozone/oxygen, much like an enema, has been used to treat colitis, fistula, immune problems and colon cancer. Topical ozone is excellent for the treatment of infected wounds, ulcers and burns, especially those that are difficult to heal.
Therapeutic Indications Of Ozone
- Vascular disease: stroke, obstructive arteriopathy, venous insufficiency.
- Immune diseases: cancer, acute and chronic viral diseases, bacterial and fungal infections.
- Skin and mucus membrane diseases: ulcers, infected wounds, gangrenes, burns, and inflammatory bowel diseases respond to ozone therapy. It is used in dentistry as a disinfectant, in pediatrics for the treatment of viral and bacterial infections of the intestines and in geriatrics for circulatory disorders and to increase the oxygen supply to the brain.
How does homeopathy work?Homeopathic medicines stimulate and encourage the body’s natural healing capability. Medicines are selected after a careful history taking and prescribed by matching the effect of a specific medicinal substance to the symptoms presented by a patient. The homeopathic principle of treating like with like is based on treating an illness with a substance that produces symptoms in a healthy person similar to those experienced by the patient. For example, Ipecacuanha (from the root of the plant) if taken by a healthy person will cause vomiting, but if taken in tiny, homeopathic doses will cure vomiting.
Is homeopathic medicine safe?Homeopathic medicines are completely safe with no side effects and they are non-addictive. They are safe for babies, children and the elderly people.
What are homeopathic medicines made from?There are more than 2,000 homeopathic medicines. They are usually prepared in the form of granules, tablets or liquids by modern laboratories in scientific conditions to the highest quality standards. They are prepared from pure, natural animal, vegetable or mineral substances that are listed in the Homeopathic Pharmacopoeia of the United States.
How do I take homeopathic medicines?The granules should be allowed to dissolve in the mouth or under the tongue, preferably taken apart from food or drink. The frequency of the dose and the potency of the medicine may vary according to the type of condition, as recommended by your doctor. The potency of the medicine is denoted by a number which follows its name. For example, Arnica 6x or Cantharis 30x. Dosing should be stopped when the condition is cleared. Proper diet, regular exercise and adequate sleep will, of course, enhance the treatment. Avoid handling the granules to prevent contamination. Tip them into the cap of the container or use a clean spoon. Keep the medicines in a cook, dark place away from strong smelling substances and they will remain effective for several years.
Intravenous Vitamin C
Vitamin C by intravenous therapy was originally pioneered by Dr. Fredrick Klenner in the 1950’s. He showed that vitamin C in intravenous doses could prevent the fatal effects of many serious diseases such as viral meningitis, insect stings and polio. Since the work of Dr. Klenner, many other physicians have reproduced this work with similar findings. Some physicians use a dose of up to 200 gms/day of vitamin C by intravenous therapy for treating serious diseases like cancer and HIV.
Dr. Hallee uses a 25 gm/500 ml sterile water dose as a general treatment. Higher doses are given, but careful examination of the patient precedes the higher dose therapy.
Functions Of Vitamin C
- Collagen synthesis: hydroxylation of lysine, essential for the hydroxylysine cross-links in collagen. Ascorbic acid acts as a reducing agent and keeps both of the above enzymes active. These connective tissues include cartilage, dentin, skin, and bones.
- Norepinephrine (adrenaline) synthesis: Injections of vitamin C into the brain increases the conversion of dopamine to epinephrine. It may be valuable in the treatment of schizophrenia, chorea, dyskinesia. Some researchers have noted that schizophrenics metabolize vitamin C 10x faster than normal.
- Aids the absorption of iron: Vitamin C works by reducing ferric iron to ferrous iron. It works best when taken with foods containing iron or iron supplements. In addition it blocks the degradation of ferritin to hemosiderin, a form of iron storage that is a considerably less bioavailable form. It thus provides a more easily available source of iron. • Steroid hormone synthesis: ACTH stimulation causes marked loss of ascorbic acid from the adrenal cortex. ACTH is primarily involved with glucocorticoids-cortisol.
- Antioxidant: Vitamin C is a powerful reducing agent and seems to work synergistically with other antioxidants such as glutathione and vitamin E. At the branched sites of arteries where atherosclerotic plagues are the most abundant vitamin C levels are the lowest.
- Drug metabolism and detoxification
- Carnitine synthesis
- Degradation of cholesterol
- Regulates cellular humoral immune function and increase macrophage activity
- Cancer prevention
- Activates certain vitamins into their active forms: conversion of folacin to tetrahydrofolic acid, tryptophan to 5-hydroxytryptophan and eventually serotonin.
- Antihistamine effects: at doses over 6-8 g q.d.
Indications For Intravenous Vitamin C
- Macular Degeneration
- Diabetes mellitus
- Heavy metal detox
- Viral or Bacterial infection (eg Hepatitis)
- Post surgical ound healing
Intravenous Vitamin C And Heavy Metal Detoxification
Lead - Vitamin C has been shown to be as effective as EDTA in chelating lead from the body.
Mercury - Megadoses of vitamin C is effective in mercurial poisoning. One scientist noted that if guinea pigs were given a preventative dose of vitamin C, instead of 100% dying from mercuric chloride poisoning, 40% survived. When you translate the body weight of a guinea pig to a human, the doses required to provide protection are about 35 gms/day. Up until the late 1960’s, vitamin C was the treatment of choice in fatal poisonings by mercury.
Intravenous Vitamin C and Cancer
Ascorbic acid and its salts are preferentially toxic to tumor cells in vitro and in vivo. Given in high enough doses to maintain plasma concentrations above levels that have been shown to be toxic to tumor cells in vitro, Ascorbic acid has the potential to selectively kill tumor cells in a manner similar to other tumor cytotoxic chemotherapeutic agents. Many studies of ascorbic acid (AA) and cancer to date have not utilized high enough doses of AA to maintain tumor cytotoxic plasma concentrations of AA.
References:Riordan NH, Riordan HD, Meng X, Li Y, Jackson JA Intravenous ascorbate as a tumor cytotoxic chemotherapeutic agent. Med Hypotheses 44 (3): 207-213 (Mar 1995)
Chelation Therapy - Heavy Metals: More Than Music
Contamination of water, air, and food by numerous chemicals and non-essential elements, such as heavy metals, is an unfortunate product of an industrialized, high-tech society. As a result , accumulation of heavy metals in the human body creates a significant health risk, leading to a wide array of problems including anemia, learning deficits, reduced intelligence, behavioral and cognitive changes, tremor, gingivitis, hypertension, irritability, cancer, depression, memory loss, fatigue, headache, hyperuricemia, gout, chronic renal failure, male infertility, osteodystrophies, and possibly multiple sclerosis and Alzheimer's disease. Toxic metals, such as lead, mercury and cadmium, are very dangerous to delicate tissues in the body. They inhibit critical energy producing enzyme function and increase free radical production.
Minerals comprise 4 percent of total body weight. Without them the body’s immune and energy production systems can’t work properly, and our ability to heal is impaired. Heavy metals commonly disturb mineral balance and thereby disrupt our health. Unfortunately, these micro and macronutrients are displaced by heavy metals, which mimic them. The body is tricked into using these dangerous toxins because it can’t tell the difference between them and the real thing. For example, lead imitates calcium and the body stores it in the bones. This contributes to a weakening of bone structure. One study has shown that children whose mothers were exposed to lead while pregnant typically end up with weaker tooth structure and more dental cavities. Heavy metals also compete with certain minerals and upset many enzyme reactions inside the cells.
Chelation - Getting Rid Of Metal Toxins
The word chelation comes from the verb “chelate”, a word derived from the Greek noun chele, which means the claw of a crab. Chelation is a “natural” process of attaching substances, usually amino acids, to metallic elements. Chelation is nature’s marriage ceremony: it weds two substances , a mineral and an organic molecule, into a compatible working partnership. Our bodies use chelation inside of the cells of our body and through out creation. For example, chlorophyll, the plant-greening pigment, is a chelate of magnesium. Hemoglobin, the oxygen-carrying pigment of red blood cells, is a chelate of iron. The chelation process is involved in the formation and function of many enzymes inside the cells of our body.
Our body already uses chelation to remove dangerous heavy metals from the blood through the liver and kidneys. Before considering a protocol for removing heavy metals, begin by evaluating the burden of heavy metals on your body. Many doctors don’t include testing for the presence of heavy metals in their preliminary work-up.
Most people have no idea that they have been exposed to these toxins. Mercury, aluminum, lead, and cadmium are the most commonly detected toxic metals. Toxic metals, such as lead and cadmium, inhibit vital enzyme function and also increase free-radical production. Exposure to these metals can cause high blood pressure, artery disease, kidney disease, and neurological problems.
Human lead toxicity continues to be a significant problem, especially in urban areas, where lead-based paint exposure is still an issue, and in areas where lead is mined and/or smelted. Mercury toxicity from occupational, environmental, dental amalgam, and contaminated food exposure, is a significant threat to public health. Other heavy metals like cadmium and arsenic, can also be found in the human body due to cigarette smoke, and occupational and environmental exposure. Diagnostic testing for the presence of heavy metals, and subsequently decreasing the body's burden of these substances, is an integral part of the overall treatment program for individuals wishing to have optimum health.
There are three main strategies which are used for chelation, each one has a different application and a proper treatment program should be chosen after careful lab evaluation by a physician. The most common and recognized form of chelation therapy is an intravenous treatment with EDTA.
Clinical experience has shown that EDTA improves metabolic and circulatory function by removing toxic metals (such as lead and cadmium) and abnormally located nutritional metallic ions (such as copper and iron) from the body. This is accomplished by administering a synthetic amino acid, EDTA (ethylene-diamine-tetra-acetic acid) , by an intravenous infusion using a tiny 25-gauge needle.
EDTA pulls abnormal metals out of the body, thus reducing the production of free radicals and preventing the conditions under which scum builds up on blood vessel walls. It is an amino acid molecule with unique and valuable therapeutic properties, one of which is its powerful attraction for loosely bound metals, especially those that speed free radical damage. EDTA binds tightly to many minerals and therefore you must take an extra supplement of minerals to replace the removal of necessary minerals. When essential minerals are where they are supposed to be, they are so tightly bound to the sites of normal activity that they are not easily removed. The metallic ions most apt to be removed by EDTA chelation are those that are loose and free-floating. Because this does not hold true all of the time, naturopathic physicians are careful to provide nutritional supplements to replace essential metals.
Chelation therapy has been proven to increase blood flow throughout the body. It has been reported to improve liver function, improve blood cholesterol ratios, lower blood fats, reduce blood pressure, reduce leg cramps, improve vision, relieve angina pains, relieve symptoms of senility, heal ulcers caused by poor circulation, forestall heart attacks and strokes, and improve memory.
It takes only very slight vascular changes to significantly alter blood flow. Of the thousands of arteries in the body, most are so slender that they have passage space no wider around than a human hair. Most capillaries are so narrow that single blood cells must fold themselves in half to squeeze through. Such tiny pathways block easily —and small changes may unblock them. When blood moves through narrow vessel walls that are blocked, a mere 19 percent increase in the diameter of a vessel will double the flow rate. The blood vessels inside patients with cardiovascular disease are not thin and smooth: they are usually filled with plaque and create turbulent flow. Poiseuille’s Law of Hemodynamics says that in the presence of turbulence, it takes less than a ten percent increase in diameter for a doubling of blood flow. EDTA opens up these plaques and provides rapid relief from atherosclerosis in many patients
Biochemists have long been acknowledging that sulfur containing compounds have the ability to chelate metals. The sulfur containing amino acids found in our body including methionine, cysteine, N-acetylcysteine, S-adenosylmethionine, alpha-lipoic acid, and the tri-peptide glutathione (GSH) all help in the chelation and excretion of metals from the human body. By helping our “inner” chelation system by adding more sulfur amino acids, we can give extra help in releasing these toxic metals form our body.
DMSA (meso-2,3-dimercaptosuccinic acid), is a water-soluble, sulfhydryl-containing compound which when given in pill form, is an effective chelator of heavy metals, especially mercury and lead. Initial studies over forty years ago identified DMSA as an effective antidote to heavy metal poisoning. DMSA was subsequently studied for twenty years in the People's Republic of China, Japan, and Russia before scientists in Europe and the United States "discovered" the substance and its potential usefulness in the mid-1970s.
While on DMSA, additional nutrient therapy is recommended and this includes hydrolyzed whey protein, as it contains cysteine and cysteine residues which can be of benefit while using DMSA. Cysteine is the rate-limiting step in glutathione production, necessary for fecal heavy metal excretion and hepatoprotection. Whey also contains branched-chain amino acids, which will occupy transport sites at the blood-brain barrier, effectively keeping bound metals from being re-deposited in the brain.
Usually DMSA is given for three days during which time all mineral supplements are stopped. This can be repeated twice a month.
DMPS (sodium-(2,3)-dimercaptopropane-(1)-sulfonate) is usually given for diagnostic purposes (urine challenges) and acute mercury toxicity (inorganic, metallic, organic). When it is given orally or intravenously, DMPS is effective at removing mercury from the kidneys whereas DMSA seems to be more effective in removing mercury from the brain and liver. DMPS is an excellent diagnostic tool to evaluate the effectiveness of a mercury detoxification program.
The individual dosage schedule depends on the severity of the intoxication and on the other methods of treatment employed. About 3-5 mg/kg body weight are administered. For example, one 5ml vial is sufficient for a 183 pound man. Usually, there is 24 hour urine collection after IV administration and sent to the lab for mercury elimination status.
Chronic Pain Management
Chronic Pain treatments
Dr. Hallee has developed effective programs for treating acute and chronic pain. The key point is to individualize therapy for the stage of the injury. Depending on the stage of an injury, a treatment program will be put together specifically for that problem. All injuries and musculoskeletal pain have 3 stages of progression.
- Chronic Loss Motion
Stasis, or stagnation of motion and circulation is the primary cause of chronic suffering and stasis is the main cause of chronic pain and inflammation. In an acute injury, the patient should be treated using a game plan to intervene with the SWELLING of stage 1. Treatments for stage 1 should stop the inflammatory cascade of prostaglandins, kinnins, histamine, seratonin, platelet aggregation factors and fibrin formation. Accurate intervention in this stage, as well as the next stage, STASIS, is critical for optimum case management. Treatments for stage 2, STASIS, will stimulate circulation, move inflammatory end products out of the site of inflammation, prevent infection and stimulate wound healing. Treatments for stage 3, CHRONIC LOSS OF MOTION, will rehabilitate joint, tendon and muscle function, stimulate circulation, stimulate collagen repair, stretch scar tissue, and strengthen the vitality of organs of detoxification and elimination.
Chronic Pain Strategies
Replace Nutrients: specific nutrients like omega 3 fatty acids decreased stiffness and pain with no side effects. Minerals, bioflavonoids, antioxidants and amino acids are all individualized for each patient.
Enhance Digestion: optimum intestinal health can correct unhealthy bacteria which cause joint inflammation and chronic muscle pain. Bacterial liposaccharides which are toxins from the bowel bacteria, have been shown to disturb the maintenance of healthy joints. Therapy programs correct intestinal permeability, food intolerence, bacterial imbalance, immune globulin deficiency, and diminished enzymes in digestion.
Diminish Inflammation: bioflavonoids, amino acids and phytochemicals diminish chemical cascades of pain chemicals to balance the body chemistry. Natural proteolytic enzymes, herbal prostaglandin, leukotriene, and thromboxane blocking agents, and botanical circulation enhancers “move blood” and resolve pain and inflammation
Optimize Motion: all therapies must enhance motion of joints, soft tissue, and fluids in the body (blood, lymph, cerebrospinal fluid). The use of direct manipulation, fascial release, soft tissue “sculpting”, acupuncture, bee venom therapy, neural therapy, ultrasound, and hydrotherapy is applied according to the type of injury and stage of inflammation.
Dr. Hallee applies these strategies according to needs of each patient.
Acupuncture and Traditional Chinese Medicine
Glutathhione was discovered in 1888 and introduced into biochemistry in the 1920s In the late 1920s and 1930s, there was a burst of research activity on glutathione, particularly in ophthalmology. The reason the research tapered off was the instability of glutathione assays. Being a powerful antioxidant, it is very sensitive to air, light and heat. It oxidizes so fast it is hard to assess its true value before it degrades or oxidizes.
Reduced glutathione (GSH) is a substance made in the cells of our body and is unique because it is both a reducing and a conjugating agent. This means that it is a major antioxidant as a free radical scavenger and an essential component of phase two liver detoxification. It’s an unusual amino acid because it can do two jobs to protect us from toxins: First, it neutralizes free radicals in our body, like toxic compounds from Phase 1 detoxification. Second, it combines with Phase 2 toxic chemicals to form a water-soluble conjugate that can be excreted in the bile and urine. Because glutathione is not broken down easily by digestive enzymes in the intestines, it’s available to intestinal cells for local “first pass” detoxification.
There are also other important functions of glutathione. Besides protecting cells against the destructive effects of radicals and detoxifying substances such as drugs and environmental pollutants, it also maintains cell membrane stability. Glutathione has been found to regulate protein and DNA biosynthesis, cell growth and it enhances immunologic function through it's effects on lymphocytes.
Ninety percent of the glutathione in a normal cell is in the cell cytosol or fluid, the rest is in the powerhouse of the mitochondria. Doctors specializing in nutritional medicine feel that small decreases in mitochiondrial GSH can result in cell death. Unfortunately mercury such as the material found in dental amalgams, preferentially targets mitochondria and GSH depletion. This is one of the main reasons dental mercury can do so much damage.
The body must manufacture glutathione from other amino acids in the liver for more efficient detoxification in the blood. It is found in fruits and vegetables and is assembled in the body from the amino acids glycine, cysteine, and glutamic acid. Glutathione deficiency comes from poor diet, free-radical stress, and toxic overload. The recommended dosage of glutathione consists of daily servings of fresh fruits and vegetables.
Biological Aging And Glutathione
Glutathione, the tripeptide amino acid composed of glutamic acid, cysteine and glycine got its’ first link between aging when it was discovered in the aging human lens. Today, all eye diseases are linked to depleted levels of glutathione. The widespread functions of glutathione indicate that the level of glutathione in ones body has major health effects on the molecular, cellular and organ levels of the individual. One author’s research showed that correction of glutathione deficiency can enhance longevity in the mosquito by 40%. In studies of healthy men and women, glutathione levels were significantly lower in the elderly (60 to 79 years) when compared to mature (40 to 59 years) subjects. However, levels in the very old (80-99 years) were similar to those of the mature group. People who maintain high levels of glutathione represent survivors with extreme longevity.
There are few studies with definitive answers on how to correct glutathione deficiency efficiently. Two basic approaches are to use precursors of glutathione such as N-acetylcysteine and secondly to give glutathione itself. Instead of waiting for disease to occur and then treating it, physicians should use glutathione tests as a diagnostic tool and use glutathione in the form of drug or food supplements to slow down or reverse accelerated aging changes at the cellular level before they advance into predisease or frank disease states.
Why Use Inravenous Glutathione?
Witschi, Reddy and Stofer and Lauterburg have established that glutathione in oral doses does not cross the intestinal barrier. Taking oral glutathione does not increase plasma glutathione levels because the hydrolysis of glutathione by intestinal and liver enzymes (gamma-glutamyl transferase). In one study 7 healthy volunteers were given oral glutathione and it was found that the concentrations of glutathione, cysteine and glutamate in plasma did not increase significantly. To significantly increase glutathione in the blood stream, intravenous application is necessary. Although studies have demonstrated the effectiveness of glutathione supplementation in some conditions, we feel that boosting glutathione levels, other than by dietary means, is not a good idea. Eating fresh fruits and vegetables provides adequate glutathione for localized intestinal detoxification. Other oral agents besides supplemental glutathione which help maintain or elevate glutathione levels include N-acetyl-cysteine, cruciferous vegetables, resh fruits, grape seed and pine bark extract, melatonin, milk thistle, bilberry, turmeric, lipoic acid, selenium and vitamins E and C.
Who Should Use Intravenous Glutathione?
For many patients who have problems with severe toxicity, central nervous system damage, kidney disease and cardiovascular disease, Meditrine Clinic has been using intravenous glutathione with excellent results. Since it does not absorb well from the gut, the intravenous route has shown promise as a powerful way to offer protection to the body with a tool that is fast and effective. Two very interesting medical studies have been published showing dramatic results with intravenous glutathione. One study showed that patients after a heart attack were benefited by intravenous glutathione. Another study was done in Italy by a neurologist named Sechi who showed that intravenous glutathione (600mg twice daily) significantly improved patients with early Parkinson’s disease giving a 42% decline in disability.
Glutathione and Aging
Julius, M Sc.D. "Glutathione and Morbidity in a Community-Based Sample of Elderly," The Journal of Clinical Epidemiology, 1994;47(9):1021-1026. This study evaluated blood glutathione levels in 33 subjects over the age of 60. Higher glutathione levels were associated with fewer number of illnesses and higher levels of self-rated health, lower cholesterol and lower body mass index and lower blood pressures. Those who had diagnoses of arthritis, diabetes or heart disease had at least marginally significant lower glutathione levels than those who were disease-free. Glutathione, together with age and measure of suppressed anger, accounted for 39% of the variance of an index of morbidity. Glutathione by itself accounted for 24% of the variance. The authors note that this study appears to be the first study showing an association of higher glutathione levels with higher levels of physical health in a community-based sample.
Glutathione and Heart Attack
Altomare, Emanuele, et al."High-Dose Antioxidant Therapy During Thrombolysis in Patients With Acute Myocardial Infarction," Current Therapeutic Research, February, 1996;57(2):131-141.
This study evaluated 67 patients with a myocardial infarction treated with recombinant tissue-type plasminogen activator (rt-PA), of which 35 received glutathione at an intravenous bolus initially of 1800 mg followed by 20 ug/kg per minute for the next 24 hours. Intravenous glutathione appears to limit the adverse effects associated with reperfusion-induced oxidative stress. If confirmed, the authors feel that glutathione administration should be considered a natural free radical antagonist that has a high specificity and low toxicity in humans.
This study highlights the clinical fact that intravenous glutathione is a powerful way to treat many acute and chronic diseases that have oxidative damage as the cause. In my clinic, intravenous glutathione is a standard treatment for neurological diseases, cancer, cardiovascular diseases and diseases related to toxicology.
Glutathione and AIDS
Vallis, K.A., "Glutathione Deficiency and Radiosensitivity in AIDS Patients", The Lancet, April 13, 1991;337:918-919.
It is known that AIDS patients have low glutathione levels. The author states that N-acetyl-L-cysteine (NAC) inhibits HIV replication and it may do so by replenishing intracellular glutathione. It has been suggested as a beneficial therapeutic agent in AIDS and though untested it may be of benefit in glutathione deficient AIDS patients who are undergoing radiotherapy. This may help prevent some of the unwanted side effects in tissue destruction due to radiation therapy.
Cathcart, Robert F., III, M.D., "Glutathione and HIV Infection", The Lancet, January 27, 1990;335:235.
Dr. Cathcart points out that very high dose vitamin C can reduce oxidized glutathione (GSSG) to GSH. Dr. Cathcart has treated over 250 HIV-positive patients since 1983 and has been found that with an increased severity in AIDS there is an increased bowel tolerance to ascorbate. The sickest individuals could tolerate between 100 to 200 gms/d in hourly dosages titrated to the point of diarrhea. He goes on to point out that high dose vitamin C can cause a slowing or reduction in the depletion of CD4 T-cells, reduced allergic reactions to antibiotics, reduction in lymphadenopathy and improvement in malaise. To achieve this he advocates to use vitamin C as intravenous sodium ascorbate without preservatives at ph of 7.0 in 60 gram dosages in 500 mls of Ringer's Lactate over three to four hours one to three times daily. Oral ascorbic acid was also given concurrently. Intravenous ascorbate does not produce diarrhea as does the hyperosmotic diarrhea induced by oral administration. Ascorbate is utilized as a free radical scavenger in these massive dosages when glutathione is exhausted and is effective in protecting glutathione levels therefore intravenous vitamion C should be considered a type of adjunctive glutathione therapy.
Glutathione and Cancer
Glutathione therapy can reduce the toxicity of some chemo agents. In one study (Tedeschi), the toxicity of cisplatin, an effective drug in the treatment of solid tumors, was greatly reduced. It is proposed in this article that glutathione is a promising antidote. Glutathione is a safe compound that prevents cisplatin-induced nephrotoxicity without affecting its antitumor activity. This would enhance the ability to use higher doses of cisplatin and improve efficacy against certain tumors. The advantage of the combination of glutathione with high doses of cisplatin was demonstrated by the impressive response rate in the treatment of ovarian cancer.
- Sechi G, M.D. "Reduced Intravenous Glutathione in the Treatment of Early Parkinson's Disease," Prog Neuro-Psychopharmacol & Biol Psychiat, 1996;20:1159-1170.
- Tedeschi M, et al Glutathione and Detoxification, Cancer Treatment Reviews, 1990;17:203-208.
- Witschi A, Reddy S, Stofer B, Lauterburg BH, "The Systemic Availability of Oral Glutathione," Eur J Clin Pharmacol, 1992;43:667-669
Bee Venom Therapy
Bee Venom has been used for thousands of years to treat arthritis. The ancient Egyptians used to sting patients directly to the site of arthritic swelling and pain. The Egyptians also used a mixture of crushed bees rubbed onto the scalp to cure baldness. Greeks, Romans and European physicians also knew of the healing power of bees. Homeopathic doctors have used dilutions of honey bees for two hundred years to treat abscesses, swelling of extremities, asthma, arthritis, kidney failure, inflammation of mucous membranes, meningitis, pharyngitis, urethritis and side effects of vaccination.
The method of discovering the usefulness of bee venom for therapeutic purposes has been mostly empirical. We see that any symptom that has heat and swelling, especially in the extremities can be helped with bee venom.
Mechanisms Of Action
Although there is not a single mechanism which explains the wide range of treatment application of BVT, several mechanisms have been proposed. Three components of bee venom, melittin, MCD-peptide and apamin seem to describe the effectiveness of it for the treatment of disease.
- Apamin has a high affinity for the central nervous system and is probably responsible for the beneficial results in treating MS patients.
- Melittin interferes with the cellular membrane enzyme phospholipase A2 and is probably responsible for the beneficial result in treating arthritic patients.
- MCD-peptide is a powerful anti-inflammatory agent. The immune system is a complicated web of communication between the “brain and bone marrow”.
Bee venom stimulates key centers in the immune system by stimulating a non specific response. It appears to stimulate cortisone secretion, enhances antibody production, and affects cytokine production. It is also a powerful inhibitor of prostaglandin formation and a membrane antioxidant. According to Forster from Germany, the pharmacological effects of bee venom are based on all of its components.
It has been found that phospholipase A2 acts in a synergistic way with melittin to lyse erythrocytes under conditions where neither alone is sufficient. Phospholipase A2 (PLA2) has been implicated in the management of arthritis1 . Arachidonic acid that is mobilized from cell membranes by PLA2 creates prostaglandins which are the basis of inflammatory processes in the body.
Consider the case of Gardner.
“Dr. Packer of Kansas City in 1904 reported the case of a man named Gardner, who had been afflicted with articular rhematism for four years, unable to walk except with the help of crutches. In August 1903, he was hobbling around the yard when he fell against a bee hive and upset it. The enraged bees pounced on him and he was very nearly stung to death. He became ill. but after recovering found that his rheumatism had disappeared, suffering no further attacks.”,?
Dr. Hallee's Specific Bee Venom Therapy Indications
- Arthritis: osteoarthritis, DJD, rheumatoid arthritis.
- Neuromusculoskeletal pain: fibromyalgia, whiplash, chronic pain syndromes, painful scars.
- Autoimmune diseases : SLE, RA, MS, Scleroderma
- Iritis and other eye disorders
- Painful scars
Conditions Treated Treated With Bee Venom
- Muscular Rheumatism
- Neuritis, neuralgia
- Migraine headache
- Acute rheumatic fever
- Acute and chronic arthritis
- Surgical inflammation of soft and bony tissues
- Spinal disc injuries
- Multiple sclerosis
- Post herpetic neuralgia
- Non healing fractures and wounds
Composition Of Bee Venom
|Class of Compound||Component||% Dry Weight|
|Peptide 401(mast cell degranulating peptide)||2%|
|Low molecular weight Constituents||Dopamine||.13-1%|
Known allergy to bee venom, kidney disease, advanced cardiovascular disease, tuberculosis.
N.B. Many people say that they are allergic to bee venom when in fact they are allergic to hornet venom. There is very little cross reactivity between bee venom and other insect venoms.
Painful areas are palpated for specific localised tender points and 0.05ml of bee venom and 0.05ml of lidocaine (to reduce the pain of the injection) is injected interdermally to imitate a bee sting. In case of an anaphalactic allergic reaction, use of epinephrine is used or if the reaction is uncomfortable and not life threatening, an injection of Benadryl will be used. Itching and swelling are common.
Length of treatment
Generally, 2 treatments per week for 4-6 weeks is sufficient for a therapeutic trial but for severe degenerative conditions longer treatment periods (with breaks) may be helpful.
There is usually a slight stinging sensation with the injection. There is occasionally an aching sensation in the area of the sting. This may be immediate or delayed. It is common for there to be some degree of immediate pain relief, mild euphoria, local itching and a feeling of warmth.
These symptoms vary from person to person and over the course of treatment. In the event of itching we recommend brushing the skin with a soft brush. The application of a cold compress has proven to be effective in reducing itching and swelling.
In addition to local itching, some patients will experience a flu-like feeling for a few hours or days. There is likely to be a systemic immune response. It frequently signals a beneficial improvement and has been much valued by BVT practitioners.
Interference with Treatment
Alcohol ingestion should be avoided by the patient during the course of treatment as it tends to inactivate the bee venom. Reactions to BVT while intoxicated have been reported.
Patients who are using immunosuppressive drugs (methotrexate, immuran, prednisone) and NSAIDS during the treatment sessions tend to not get optimum results.
Patients seem to have better results when they are taking extra multiple vitamins, mineral and anti-oxidents during the treatment. Adding DHEA or adrenal steroid precursors are also a definite benefit. Using other nutrients which have a known benefit in a particular disease process will also help the results. These should be used under Dr. Hallee’s or another naturopathic physician’s advice.
Stress Management and the role of DHEA
Stress hormones are molecules that travel throughout the body delivering messages to other cells about our level of pain . When our stress hormones are in balance, we feel terrific. When they are out of balance we can feel exhausted, depressed, have poor immune function, sexual problems, and get fat even though we don’t eat that much.
Stress creates a feeling that does not feel good in our body. Wouldn’t it be nice to have a way to evaluate the damage of stress hormones and then do something about it?
Stress disturbs the balance of adrenal hormones. Abnormal levels of adrenal hormones are a frequent undiagnosed cause of emotional and mental distress. Adrenal hormones exert a profound influence on the body's carbohydrate, protein, and fat metabolism, immune response, thyroid function, cardiovascular health, and overall resistance to stress.
First step is to use adrenocortex hormone testing using samples of saliva to evaluate levels of the body's stress hormones. This profile serves as a tool for uncovering hormone imbalances that can cause anxiety, depression, chronic fatigue, obesity, diabetes and a host of other clinical conditions. Although hormones can be tested through blood, research shows that free hormones can accurately measured through saliva. Free hormones are unattached and therefore are the worker bees. They easily pass through cell membranes, whereas bound hormones do not. Traditional hormone testing from a standard medical lab lumps all free and bound hormones together. Assessment of salivary free hormones gives a more accurate picture of what’s really going on. It's also a crucial tool for monitoring DHEA and/or cortisone therapy.
What Are Adrenal Hormones?
On top of the kidneys are two small glands called adrenal glands which are essential for life. When you feel physical or psychological stress, these glands release natural chemicals such as adrenaline, DHEA, and cortisol (called adrenal hormones) and up to fifty other hormones directly into your bloodstream.
What is DHEA
DHEA is the most abundant steroid hormone and during stress, to produce cortisol, the body shunts away from DHEA, testosterone and estrogen. Depending on the need, the body will produce either testosterone or estrogen from DHEA. In addition to protecting the body’s sex hormones, DHEA also protects the immune system. DHEA helps in fighting diseases like AIDS and cancer. DHEA increases sensitivity to insulin, increases fat metabolism, increases antioxidant enzymes in the liver, helps to scavenge free radicals.
People with chronic disease of any sort commonly have low DHEA.
Cortisol overproduction is even more damaging when accompanied by low levels of DHEA. DHEA protects cells from the physical and mental damage caused by stress is unknown. Fifty percent of all the hormones secreted by the adrenal gland is DHEA. Large quantities of DHEA are made by the body because it is used as a building block for making other important hormones like estrogen and testosterone. Low levels of DHEA have a powerful effect on our immune system, sex drive, mood, sleep, fat distribution, bone health and our mood. DHEA supplementation has been shown to improve memory function, boost energy levels, and reduce fat production.
Most importantly, DHEA appears to protect the immune system from some of the cell damage caused by aging and disease. At an advanced age, your DHEA levels may have dropped 80-85% from their youthful levels.
Low levels of DHEA have been found in people with chronic fatigue syndrome, lupus, arthritis, insomnia, high blood pressure, Alzheimer's cancer, heart disease, and nearly all diseases of aging. DHEA is being used therapeutically and testing can determine appropriate supplemental levels.
Cortisol, the main stress hormone comes from the adrenal gland cortex. It is an hormone essential for life and has been largely ignored in treating many chronic health problems. Cortisol levels rise dramatically with stress, prolonging your body's "fight or flight" response. If your body is producing too much or too little cortisol, you may feel certain symptoms. Anxiety, depression, heart disease, AIDS and osteoporosis have all been linked with elevated cortisol levels. Adrenal hormones are very important for appropriate immune function. Research has shown that animals who have their adrenal glands removed, will die due to decreased immunity, and it is well established that lack of cortisol results in more susceptibility to bacterial toxins. Since normal hospital ranges for adrenal cortical function have been based on the deficiency state of Addison's disease, or on an excess condition such as Cushing's syndrome, these ranges need to be revised to milder degrees of insufficiency.
DHEA and Cortisol Ratios
As we age, we naturally tend to produce less DHEA and cortisol levels may continue to increase over time. If these two hormones remain chronically "out of sync," it can tax the body's immune system, making a person less able to cope with stress and more susceptible to a wide range of illnesses. Low DHEA/cortisol ratios have been found in patients with surgical stress, depression, drug toxicity and weight loss. Change in this ratio signals early changes as the body loses its ability to respond to stress, aging and disease.
Early Stress Adaptation = high cortisol/low DHEA
Lab indicators: decreased insulin sensitivity, decreased glucose utilization, increased blood sugar, increased calcium loss, increased fat accumulation at waist, increased protein breakdown, increased water retention, decreased secretory IgA, decreased NK cell activity, decreased interleukin, decreased lymphocytes
Signs And Symptoms: increased infections, increased viral infections (CMV, herpes), increased yeast overgrowth, increased allergies, increased insomnia, reduced vitality, reduced sex drive, increased hunger, premenstrual tension
Late Stress adrenal exhaustion = low cortisol/low DHEA
Lab indicators: low blood sugar, decreased energy production, depressed immune function
Signs And Symptoms: alcohol intolerence, allergies, chronic fatigue, chronic inflammation, degenerative diseases, depression, headaches, hypoglycemia, hunger, irritability, inability to concentrate, muscle weakness, poor memory, premenstrual tension, low sex drive
Clinical Indications for Cortisol and DHEA Testing
- Auto immune Disease
- Chronic Fatigue
- Multiple Sclerosis
- Hair loss in women
- Allergic Sensitivity
- Immune dysfunction
- Rheumatoid Arthritis
- Reduced Tissue strength
The adrenal glands produce the hormones cortisol and DHEA. Cortisol prolongs the "flight or fight” response by promoting a sustained "rush" of energy. Over time, over-secretion of cortisol--triggered by daily stress from family, work, sports can cause fatigue and burn-out of cortisol production.
Some researchers believe that Chronic Fatigue Syndrome (CFS) is actually a type of adrenal disease. Clinical features of chronic fatigue syndrome are similar to those with cortisol deficiency. The elevation of cortisol secretion can be important the treatment of chronic fatigue syndrome. With CFS, the adrenal dysfunction is the opposite in ordinary stress-induced fatigue. Without sufficient action of cortisol and other stress hormones, body cannot sustain the healthy "nervous energy" it needs to perform routine tasks. CFS typically show low free-cortisol levels and adrenal insufficiency.
Symptoms Of Adrenal Deficiency:
- Feverishness, joint
- Post exertional fatigue
- Exacerbation of allergic responses
- Disturbances of mood
- Fatigue Of Unknown Origin
- Enlarged or sore lymph nodes
- Muscle and joint aches
- Memory lapses
- Inability to concentrate
Bowen therapy is a profoundly relaxing and gentle technique which treats pain and imbalances in the body. Because it works on both skeletal and smooth muscles, as well as the nervous system, it is used for treatment in a wide variety of conditions. Some examples include:
- Frozen shoulder
- Pain (acute or chronic) of joints
- Childhood bed wetting
- IBD (Colitis and Crohn’s disease)
The Bowen technique achieves its effects through stimulation of the autonomic nervous system. The doctor performs a series of movements to areas on the body where muscles receive their signal from nerves. The movements then disrupt the signals that the patient was formerly receiving which allows their body to let go former patterns of pain.
What should I expect in a treatment?Treatments are usually 45 minutes in length. This allows the doctor enough time to apply the series of movements with gaps of about 2 minutes in between. These gaps are important in order for the body to integrate the new signal into the nervous system. Also important to this integration is avoiding over-stimulating activity, which is why it is not recommended to also receive treatments of massage, chiropractic adjustments, etcetera after treatment days. The doctor will give you specific details around which activities are helpful or harmful.
To prepare for your treatment, it is best to arrive in comfortable clothes that can be moved around, as some of the therapy must be done directly on the skin. This is particularly true of the lower back area. Most patients will feel a marked improvement on or before the third treatment, with most cases resolving by the fifth or sixth treatment.
Has Dr Hallee had much personal success with the treatment?
After Dr Hallee began practicing Bowen therapy in 2011, she has seen remarkable improvements in a wide variety of cases. Such cases include:
28 year old female with Crohn’s disease: Patient was hospitalized due to intestinal blockage from scar tissue. Surgery was set for the next day, but Bowen was used the day prior and patient was released during pre-surgical assessment.
63 year old female with carpel tunnel syndrome and a numb foot after a crush injury 2 years prior – Carpel tunnel resolved completely after three treatments. By the fifth treatment the numbness decreased from two full toes to a small spot just above the root of the large toe.For research papers on Bowen, please visit http://bowencanada.ca/research.html or http://www.drmanonbolliger.com/programs/a/bowen-college-resources/